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1

Update on Alzheimer's Disease Therapy and Prevention Strategies

Graham, W. Vallen, Bonito-Oliva, Alessandra, Sakmar, Thomas P.

Journal:

Annual Review of Medicine

Year:

2017

Language:

english

File:

PDF, 582 KB

english, 2017

2

Escaping the flatlands: new approaches for studying the dynamic assembly and activation of GPCR signaling complexes

Thomas Huber, Thomas P. Sakmar

Journal:

Trends in Pharmacological Sciences

Year:

2011

Language:

english

File:

PDF, 1.20 MB

english, 2011

3

Site-Specific Epitope Tagging of G Protein-Coupled Receptors by Bioorthogonal Modification of a Genetically Encoded Unnatural Amino Acid

Naganathan, Saranga, Ye, Shixin, Sakmar, Thomas P., Huber, Thomas

Journal:

Year:

2013

Language:

english

File:

PDF, 818 KB

english, 2013

4

Contributions of H G Khorana to understanding transmembrane signal transduction

Farrens, David L., Sakmar, Thomas P.

Journal:

Year:

2012

Language:

english

File:

PDF, 554 KB

english, 2012

5

Introduction: G-Protein Coupled Receptors

Sakmar, Thomas P.

Journal:

Chemical Reviews

Year:

2017

Language:

english

File:

PDF, 845 KB

english, 2017

6

Toward a framework for sulfoproteomics: Synthesis and characterization of sulfotyrosine-containing peptides

Christoph Seibert, Thomas P. Sakmar

Journal:

Year:

2008

Language:

english

File:

PDF, 372 KB

english, 2008

7

Site-specific in vitro and in vivo incorporation of molecular probes to study G-protein-coupled receptors

Kelly A Daggett, Thomas P Sakmar

Journal:

Current Opinion in Chemical Biology

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

8

Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F

Sheikh, Søren P., Zvyaga, Tatyana A., Lichtarge, Olivier, Sakmar, Thomas P., Bourne, Henry R.

Journal:

Year:

1996

File:

PDF, 905 KB

1996

9

10.1038/76976

Sakmar, Thomas P

Journal:

Nature Genetics

Year:

2000

Language:

english

File:

PDF, 413 KB

english, 2000

10

Tracking G-protein-coupled receptor activation using genetically encoded infrared probes

Schertler, Gebhard F. X., Sakmar, Thomas P., Deupi, Xavier, Vogel, Reiner, Ye, Shixin, Zaitseva, Ekaterina, Caltabiano, Gianluigi

Journal:

Year:

2010

Language:

english

File:

PDF, 799 KB

english, 2010

11

FTIR analysis of GPCR activation using azido probes

Ye, Shixin, Huber, Thomas, Vogel, Reiner, Sakmar, Thomas P

Journal:

Nature Chemical Biology

Year:

2009

Language:

english

File:

PDF, 323 KB

english, 2009

12

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

Donzella, George A., Schols, Dominique, Lin, Steven W., Esté, José A., Nagashima, Kirsten A., Maddon, Paul J., Allaway, Graham P., Sakmar, Thomas P., Henson, Geoffrey, DeClercq, Erik

Journal:

Nature Medicine

Year:

1998

File:

PDF, 640 KB

1998

13

Bilateral olfactory sensory input enhances chemotaxis behavior

Louis, Matthieu, Huber, Thomas, Benton, Richard, Sakmar, Thomas P, Vosshall, Leslie B

Journal:

Nature Neuroscience

Year:

2007

Language:

english

File:

PDF, 3.83 MB

english, 2007

14

Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation

Ahuja, Shivani, Hornak, Viktor, Yan, Elsa C Y, Syrett, Natalie, Goncalves, Joseph A, Hirshfeld, Amiram, Ziliox, Martine, Sakmar, Thomas P, Sheves, Mordechai, Reeves, Philip J

Journal:

Nature Structural and Molecular Biology

Year:

2009

Language:

english

File:

PDF, 890 KB

english, 2009

15

G protein βγ subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth

Sachdev, Pallavi, Menon, Santosh, Kastner, David B, Chuang, Jen-Zen, Yeh, Ting-Yu, Conde, Cecilia, Caceres, Alfredo, Sung, Ching-Hwa, Sakmar, Thomas P

Journal:

The EMBO Journal

Year:

2007

Language:

english

File:

PDF, 551 KB

english, 2007

16

Coupling of Protonation Switches During Rhodopsin Activation

Reiner Vogel, Thomas P. Sakmar, Mordechai Sheves, Friedrich Siebert

Journal:

Photochemistry and Photobiology

Year:

2007

Language:

english

File:

PDF, 549 KB

english, 2007

17

Opsin Is a Phospholipid Flippase

Indu Menon, Thomas Huber, Sumana Sanyal, Sourabh Banerjee, Patrick Barré, Sam Canis, J. David Warren, John Hwa, Thomas P. Sakmar, Anant K. Menon

Journal:

Current Biology

Year:

2011

Language:

english

File:

PDF, 546 KB

english, 2011

18

Structure of rhodopsin and the superfamily of seven-helical receptors: the same and not the same

Thomas P Sakmar

Journal:

Current Opinion in Cell Biology

Year:

2002

Language:

english

File:

PDF, 283 KB

english, 2002

19

How color visual pigments are tuned

Gerd G. Kochendoerfer, Steven W. Lin, Thomas P. Sakmar, Richard A. Mathies

Journal:

Trends in Biochemical Sciences

Year:

1999

Language:

english

File:

PDF, 1.45 MB

english, 1999

20

The steric trigger in rhodopsin activation

Ted Shieh, May Han, Thomas P Sakmar, Steven O Smith

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 552 KB

english, 1997

21

Reconstitution of the Vertebrate Visual Cascade Using Recombinant Heterotrimeric Transducin Purified from Sf9 Cells

K.Christopher Min, Stephen A. Gravina, Thomas P. Sakmar

Journal:

Protein Expression and Purification

Year:

2000

Language:

english

File:

PDF, 163 KB

english, 2000

22

The Role of Glu181 in the Photoactivation of Rhodopsin

Steffen Lüdeke, Mareike Beck, Elsa C.Y. Yan, Thomas P. Sakmar, Friedrich Siebert, Reiner Vogel

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 560 KB

english, 2005

23

Crystal Structure of the SH3 Domain of βPIX in Complex with a High Affinity Peptide from PAK2

André Hoelz, Jay M. Janz, Steven D. Lawrie, Brian Corwin, Adrian Lee, Thomas P. Sakmar

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 853 KB

english, 2006

24

Recognition of a CXCR4 Sulfotyrosine by the Chemokine Stromal Cell-derived Factor-1α (SDF-1α/CXCL12)

Christopher T. Veldkamp, Christoph Seibert, Francis C. Peterson, Thomas P. Sakmar, Brian F. Volkman

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 517 KB

english, 2006

25

Rapid Incorporation of Functional Rhodopsin into Nanoscale Apolipoprotein Bound Bilayer (NABB) Particles

Sourabh Banerjee, Thomas Huber, Thomas P. Sakmar

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.47 MB

english, 2008

26

Functional Role of the “Ionic Lock”—An Interhelical Hydrogen-Bond Network in Family A Heptahelical Receptors

Reiner Vogel, Mohana Mahalingam, Steffen Lüdeke, Thomas Huber, Friedrich Siebert, Thomas P. Sakmar

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 774 KB

english, 2008

27

Structural Evidence for a Sequential Release Mechanism for Activation of Heterotrimeric G Proteins

Neeraj Kapoor, Santosh T. Menon, Radha Chauhan, Pallavi Sachdev, Thomas P. Sakmar

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 1.02 MB

english, 2009

28

Nucleobindin 1 Caps Human Islet Amyloid Polypeptide Protofibrils to Prevent Amyloid Fibril Formation

Ruchi Gupta, Neeraj Kapoor, Daniel P. Raleigh, Thomas P. Sakmar

Journal:

Journal of Molecular Biology

Year:

2012

Language:

english

File:

PDF, 1.59 MB

english, 2012

29

Evidence for the specific interaction of a lipid molecule with rhodopsin which is altered in the transition to the active state metarhodopsin II

Mareike Beck, Friedrich Siebert, Thomas P Sakmar

Journal:

Year:

1998

Language:

english

File:

PDF, 140 KB

english, 1998

30

Unnatural amino acids for the study of chemokine receptor structure and dynamics

Marco Siderius, Marjolein Wal, Danny J. Scholten, Martine J. Smit, Thomas P. Sakmar, Rob Leurs, Chris de Graaf

Journal:

Drug Discovery Today: Technologies

Year:

2012

Language:

english

File:

PDF, 608 KB

english, 2012

31

SEIRA Spectroscopy on a Membrane Receptor Monolayer Using Lipoprotein Particles as Carriers

Zaitseva, Ekaterina, Saavedra, Marcia, Banerjee, Sourabh, Sakmar, Thomas P., Vogel, Reiner

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 548 KB

english, 2010

32

Rhodopsin Activation Affects the Environment of Specific Neighboring Phospholipids: An FTIR Spectroscopic Study

Isele, Jürgen, Sakmar, Thomas P., Siebert, Friedrich

Journal:

Biophysical Journal

Year:

2000

Language:

english

File:

PDF, 141 KB

english, 2000

33

Rapid Incorporation of Heterologously Expressed GPCR CCR5 in Nanoscale Apolipoprotein Bound Bilayers (NABBs)

Banerjee, Sourabh, Grunbeck, Amy, Huber, Thomas, Sachdev, Pallavi, Sakmar, Thomas P.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 35 KB

english, 2009

34

Probing Conformational Changes In Rhodopsin With Site-specific Azido Labels

Ye, Shixin, Huber, Thomas, Vogel, Reiner, Sakmar, Thomas P.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 77 KB

english, 2009

35

High-Throughput Measurement of GPCR Stability At Femtomole Scale

Knepp, Adam M., Grunbeck, Amy, Banerjee, Sourabh, Sakmar, Thomas P., Huber, Thomas

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 45 KB

english, 2011

36

Nucleobindin 1 is a Calcium Regulated Guanine Nucleotide Dissociation Inhibitor of GαI1

Kapoor, Neeraj, Gupta, Ruchi, Menon, Santosh T., folta-Stogniew, Ewa, Raleigh, Daniel P., Sakmar, Thomas P.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 102 KB

english, 2011

37

Rhodopsin Early Receptor Potential Revisited

Sakmar, Thomas P.

Journal:

Biophysical Journal

Year:

1999

Language:

english

File:

PDF, 52 KB

english, 1999

38

Curvature and Hydrophobic Forces Drive Oligomerization and Modulate Activity of Rhodopsin in Membranes

Botelho, Ana Vitória, Huber, Thomas, Sakmar, Thomas P., Brown, Michael F.

Journal:

Biophysical Journal

Year:

2006

Language:

english

File:

PDF, 501 KB

english, 2006

39

Structural Basis for Ligand Binding and Specificity in Adrenergic Receptors: Implications for GPCR-Targeted Drug Discovery †

Huber, Thomas, Menon, Santosh, Sakmar, Thomas P.

Journal:

Year:

2008

Language:

english

File:

PDF, 3.78 MB

english, 2008

40

G Protein-Coupled Receptors Self-Assemble in Dynamics Simulations of Model Bilayers

Periole, Xavier, Huber, Thomas, Marrink, Siewert-Jan, Sakmar, Thomas P.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 553 KB

english, 2007

41

Structural Determinants of the Supramolecular Organization of G Protein-Coupled Receptors in Bilayers

Periole, Xavier, Knepp, Adam M., Sakmar, Thomas P., Marrink, Siewert J., Huber, Thomas

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 1.60 MB

english, 2012

42

Probing G Protein-Coupled Receptor—Ligand Interactions with Targeted Photoactivatable Cross-Linkers

Grunbeck, Amy, Sakmar, Thomas P.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.26 MB

english, 2013

43

Mapping the Ligand-Binding Site on a G Protein-Coupled Receptor (GPCR) Using Genetically Encoded Photocrosslinkers

Grunbeck, Amy, Huber, Thomas, Sachdev, Pallavi, Sakmar, Thomas P.

Journal:

Year:

2011

Language:

english

File:

PDF, 2.52 MB

english, 2011

44

Role of the C 9 Methyl Group in Rhodopsin Activation: Characterization of Mutant Opsins with the Artificial Chromophore 11- cis -9-Demethylretinal †

Han, May, Groesbeek, Michel, Smith, Steven O., Sakmar, Thomas P.

Journal:

Year:

1998

Language:

english

File:

PDF, 82 KB

english, 1998

45

Antibody Epitopes on G Protein-Coupled Receptors Mapped with Genetically Encoded Photoactivatable Cross-Linkers

Ray-Saha, Sarmistha, Huber, Thomas, Sakmar, Thomas P.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.88 MB

english, 2014

46

Structural biology: Ion channel in the spotlight

Ernst, Oliver P., Sakmar, Thomas P.

Journal:

Year:

2012

Language:

english

File:

PDF, 602 KB

english, 2012

47

Site-Specific Fluorescent Labeling of G Protein-Coupled Receptors

Tian, He, Naganathan, Saranga, Ye, Shixin, Sakmar, Thomas P., Huber, Thomas

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 59 KB

english, 2011

48

Editorial Board

Ye, Shixin, Huber, Thomas, Sakmar, Thomas P.

Journal:

Hematology/Oncology Clinics of North America

Year:

1999

Language:

english

File:

PDF, 140 KB

english, 1999

49

Unnatural Amino Acid Mutagenesis For Site-specific Incorporation Of Keto And Azido Functionalities Into Functional G Protein-coupled Receptors

Ye, Shixin, Huber, Thomas, Sakmar, Thomas P.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 134 KB

english, 2009

50

Molecular Model of the Opsin-G-Protein Complex

Mukhopadhyay, Parag, Sakmar, Thomas P., Huber, Thomas

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 72 KB

english, 2010